منابع مشابه
Chromosome Segregation: Pushing Plasmids Apart
The ParM ATPase from Escherichia coli plasmid R1 assembles into F-actin-like filaments which appear to push replicated copies of the plasmid to opposite ends of the cell, ensuring partitioning into daughter cells. Might bacterial chromosomes use a similar mitotic strategy for segregation?
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During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces on kinetochores. What forces drive chromosome segregation in anaphase remains a central question. The current model for anaphase in human cells includes shortening of kinetochore fibers and separation of spindle poles. Both processes require kinetochores to be linked with the poles. Here we show, by comb...
متن کاملFailure of skin-deep learning.
End-on view of the atomic model of the bacterial actinlike ParM protein double-helical fi lament, generated from an electron microscopic reconstruction. A bipolar spindle of antiparallel ParM fi laments pushes plasmids to the cell poles, constituting the simplest known apparatus for the segregation of genetic information. The loops on the outside of the 8to 9-nanometer-thick fi laments are invo...
متن کاملPARM: Power Aware Reconfigurable Middleware
In distributed environments, generic middleware services(e.g. caching, location management etc.) are widely used to satisfy application needs in a cost-effective manner. Such middleware services consume system resources such as storage, computation and communication and can be sources of significant power overheads when executed on low-power devices. We present a distributed middleware framewor...
متن کاملApoptotic inaccessibility with maturity
A bacterial protein that looks like actin but acts like micro-tubules makes a Sisyphean effort to push plasmids apart, as revealed in videos by Campbell and Mullins. The prokaryotic actin look-alike is ParM, which forms a fi lament that, like microtubules, is dynamically unstable. ParM is encoded by plasmid operons that also contain centromeric sequences and the gene for a DNA-binding protein t...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1795iti5